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Furthermore HLA-DR expression is reduced in the peripheral blood DCs of elderly subjects, which leads to diminished antigen presentation and contributes to the age-related decline in immune responsiveness [256]

doi: 10.1016/j.smim.2022.101672 44 Rodrguez-FloresEMMata-EspinosaDBarrios-PayanJMarquina-CastilloBCastan-ArreolaMHernndez-PandoR

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[50] Goal-directed fluid administration using transesophageally ultrasound is therefore part of many fast-track protocols